Prof. Dr. Ingmar Glauche
© Ingmar Glauche
Group leader
NameMr Prof. Dr. rer. med. Ingmar Glauche
Deputy Institute Director
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Ingmar Glauche is deputy head of the Institute for Medical Informatics and Biometrics and leads the research group for Theoretical Stem Cell Biology. He is the coordinator of institute's teaching activities. Professor Dr. Glauche represents the Medical Faculty as an elected member of the extended senate of TU Dresden. Additionally, Professor Dr. Glauche serves as a voluntary conflict mediator at TU Dresden.
Prof. Dr. Glauche’s research focus covers the following areas:
Hematopoietic stem cell aging:
- Clonal competition and clonal dominance
- Age-related changes in the polarity of HSC divisions
Theoretical concepts of stem cell organization:
- Proliferation- and differentiation control of haematopoietic stem cells
- Clonal competition phenomena
- Cell fate regulation of mouse embryonic stem cells
Disease and treatment models:
- Chronic and acute myeloid leukaemia
- Conceptual understanding of inherited bone marrow failure syndromes
- Gene therapeutic approaches
Statistical analysis of dynamic processes and structures
- Image analysis and single cell tracking
- Analysis of cellular genealogies
Clonal tracking
- Genetic barcoding
- Analysis of multiple integrations
Publications
2023
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Correlation of Socioeconomic and Environmental Factors With Incidence of Crohn Disease in Children and Adolescents: Systematic Review and Meta-Regression, 3 May 2023, In: JMIR Public Health and Surveillance. 10, p. 1-18, 18 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
2022
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Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation, 6 Dec 2022, In: Frontiers in oncology. 12, 1028871Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift, Aug 2022, In: Life science alliance. 5, 8, 16 p., e202201408Electronic (full-text) versionResearch output: Contribution to journal > Research article
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A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase, 25 Jul 2022, In: Developmental cell. 57, 14, p. 1712-1727.e9, 26 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy, Jul 2022, In: Leukemia. 36, 7, p. 1879-1886, 8 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo, 28 Jun 2022, In: Nature communications. 13, 1, 3712Electronic (full-text) versionResearch output: Contribution to journal > Research article
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The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age, Mar 2022, In: International journal of molecular sciences. 23, 6, 18 p., 3160Electronic (full-text) versionResearch output: Contribution to journal > Research article
2021
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Does preoperative antibiotic prophylaxis affect sonication-based diagnosis in implant-associated infection?, Dec 2021, In: Journal of Orthopaedic Research. 39, 12, p. 2646-2652, 7 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Mechanistic models of blood cell fate decisions in the era of single-cell data, Dec 2021, In: Current opinion in systems biology. 28, 5 p., 100355Electronic (full-text) versionResearch output: Contribution to journal > Review article
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How to predict relapse in leukemia using time series data: A comparative in silico study, Nov 2021, In: PloS one. 16, 11, e0256585Electronic (full-text) versionResearch output: Contribution to journal > Research article