Prof. Dr. Ingmar Glauche
© Ingmar Glauche
Group leader
NameMr Prof. Dr. rer. med. Ingmar Glauche
Deputy Institute Director
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Ingmar Glauche is deputy head of the Institute for Medical Informatics and Biometrics and leads the research group for Theoretical Stem Cell Biology. He is the coordinator of institute's teaching activities. Professor Dr. Glauche represents the Medical Faculty as an elected member of the extended senate of TU Dresden. Additionally, Professor Dr. Glauche serves as a voluntary conflict mediator at TU Dresden.
Prof. Dr. Glauche’s research focus covers the following areas:
Hematopoietic stem cell aging:
- Clonal competition and clonal dominance
- Age-related changes in the polarity of HSC divisions
Theoretical concepts of stem cell organization:
- Proliferation- and differentiation control of haematopoietic stem cells
- Clonal competition phenomena
- Cell fate regulation of mouse embryonic stem cells
Disease and treatment models:
- Chronic and acute myeloid leukaemia
- Conceptual understanding of inherited bone marrow failure syndromes
- Gene therapeutic approaches
Statistical analysis of dynamic processes and structures
- Image analysis and single cell tracking
- Analysis of cellular genealogies
Clonal tracking
- Genetic barcoding
- Analysis of multiple integrations
Publications
2021
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Overlooking the obvious?: On the potential of treatment alterations to predict patient-specific therapy response, Feb 2021, In: Experimental hematology. 94, p. 26-30, 5 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
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TraCurate: Efficiently curating cell tracks, Jan 2021, In: SoftwareX. 13, 100656Electronic (full-text) versionResearch output: Contribution to journal > Research article
2020
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Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: Insights from a mathematical modelling approach: Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: Insights from a mathematical modelling approach, 1 Sep 2020, In: Journal of the Royal Society interface. 17, 170, 20200091Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission, Aug 2020, In: Leukemia. 34, 8, p. 2113-2124, 12 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Continuous mitotic activity of primitive hematopoietic stem cells in adult mice, 1 Jun 2020, In: The Journal of experimental medicine. 217, 6, e20191284Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML, 1 Jun 2020, In: Cancer research. 80, 11, p. 2394-2406, 13 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Register und Studien in der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) – Welchen Beitrag leisten sie zum Fortschritt?, May 2020, In: Klinische Pädiatrie : clinical research and practice in pediatrics. 232, 3, p. 124-135, 12 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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genBaRcode: a comprehensive R-package for genetic barcode analysis, 1 Apr 2020, In: Bioinformatics. 36, 7, p. 2189-2194, 6 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Molecular monitoring during dose reduction predicts recurrence after TKI cessation in CML, 5 Mar 2020, In: Blood. 135, 10, p. 766-769, 4 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Integration of mathematical model predictions into routine workflows to support clinical decision making in haematology, 10 Feb 2020, In: BMC medical informatics and decision making. 20, 1, 28Electronic (full-text) versionResearch output: Contribution to journal > Research article