Prof. Dr. Ingmar Glauche
© Ingmar Glauche
Group leader
NameMr Prof. Dr. rer. med. Ingmar Glauche
Deputy Institute Director
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Ingmar Glauche is deputy head of the Institute for Medical Informatics and Biometrics and leads the research group for Theoretical Stem Cell Biology. He is the coordinator of institute's teaching activities. Professor Dr. Glauche represents the Medical Faculty as an elected member of the extended senate of TU Dresden. Additionally, Professor Dr. Glauche serves as a voluntary conflict mediator at TU Dresden.
Prof. Dr. Glauche’s research focus covers the following areas:
Hematopoietic stem cell aging:
- Clonal competition and clonal dominance
- Age-related changes in the polarity of HSC divisions
Theoretical concepts of stem cell organization:
- Proliferation- and differentiation control of haematopoietic stem cells
- Clonal competition phenomena
- Cell fate regulation of mouse embryonic stem cells
Disease and treatment models:
- Chronic and acute myeloid leukaemia
- Conceptual understanding of inherited bone marrow failure syndromes
- Gene therapeutic approaches
Statistical analysis of dynamic processes and structures
- Image analysis and single cell tracking
- Analysis of cellular genealogies
Clonal tracking
- Genetic barcoding
- Analysis of multiple integrations
Publications
2019
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Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach, Jul 2019, In: Stem cells (Dayton, Ohio). 37, 7, p. 948-957, 10 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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To Cure or Not to Cure: Consequences of Immunological Interactions in CML Treatment, Jul 2019, In: Bulletin of mathematical biology. 81, 7, p. 2345-2395, 51 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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The prognostic potential of monitoring disease dynamics in NPM1-positive acute myeloid leukemia, 1 Jun 2019, In: Leukemia. 33, 6, p. 1531-1534, 4 p.Electronic (full-text) versionResearch output: Contribution to journal > Letter
2018
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A track of the clones: new developments in cellular barcoding, Dec 2018, In: Experimental hematology. 68, p. 15-20, 6 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma, 20 Nov 2018, In: Cell reports. 25, 8, p. 2208-2222.e7Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data, Nov 2018, In: Haematologica. 103, 11, p. 1825-1834, 10 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Aging alters the epigenetic asymmetry of HSC division, Sep 2018, In: PLoS biology. 16, 9, e2003389Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison, 17 Aug 2018, In: Scientific reports. 8, 1, 12330Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial, Jul 2018, In: Leukemia. 32, 7, p. 1657-1669, 13 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice, 15 May 2018, In: Nature communications. 9, 1, 1898Electronic (full-text) versionResearch output: Contribution to journal > Research article
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