Prof. Dr. Ingmar Glauche
© Ingmar Glauche
Group leader
NameMr Prof. Dr. rer. med. Ingmar Glauche
Deputy Institute Director
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Ingmar Glauche is deputy head of the Institute for Medical Informatics and Biometrics and leads the research group for Theoretical Stem Cell Biology. He is the coordinator of institute's teaching activities. Professor Dr. Glauche represents the Medical Faculty as an elected member of the extended senate of TU Dresden. Additionally, Professor Dr. Glauche serves as a voluntary conflict mediator at TU Dresden.
Prof. Dr. Glauche’s research focus covers the following areas:
Hematopoietic stem cell aging:
- Clonal competition and clonal dominance
- Age-related changes in the polarity of HSC divisions
Theoretical concepts of stem cell organization:
- Proliferation- and differentiation control of haematopoietic stem cells
- Clonal competition phenomena
- Cell fate regulation of mouse embryonic stem cells
Disease and treatment models:
- Chronic and acute myeloid leukaemia
- Conceptual understanding of inherited bone marrow failure syndromes
- Gene therapeutic approaches
Statistical analysis of dynamic processes and structures
- Image analysis and single cell tracking
- Analysis of cellular genealogies
Clonal tracking
- Genetic barcoding
- Analysis of multiple integrations
Publications
2014
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Long-term imatinib treatment does not cause testicular toxicity in male adolescents with chronic myeloid leukemia and in a juvenile rat model, May 2014, In: Klinische Padiatrie. 226, 3, p. 169-174, 6 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Multiplexing clonality: combining RGB marking and genetic barcoding, Apr 2014, In: Nucleic Acids Research. 42, 7, 10 p., e56Electronic (full-text) versionResearch output: Contribution to journal > Research article
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A model-based analysis of culture-dependent phenotypes of mESCs, 2014, In: PLoS ONE. 9, 3, p. e92496Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Model-Based Characterization of the Molecular Response Dynamics of Tyrosine Kinase Inhibitor (TKI)-Treated CML Patients – a Comparison of Imatinib and Dasatinib First-Line Therapy, 2014, In: Blood. 124, 21, 4562Electronic (full-text) versionResearch output: Contribution to journal > Research article
2013
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Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges, Apr 2013, In: Blood cells, molecules & diseases : BCMD. 50, 4, p. 232-40, 9 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
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Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia, 10 Jan 2013, In: Blood. 121, 2, p. 378-384, 7 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector, Jan 2013, In: Experimental Hematology. 41, 1, p. 28-38.e3Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Mathematical modeling of oncogenesis control in mature T-cell populations, 2013, In: Frontiers in Immunology. 4, 11 p., 380Electronic (full-text) versionResearch output: Contribution to journal > Research article
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TK inhibitor treatment disrupts growth hormone axis: Clinical observations in children with CML and experimental data from a Juvenile Animal Model, 2013, In: Klinische Padiatrie. 225, 3, p. 120-126, 7 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
2012
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On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup, Feb 2012, In: Experimental Hematology. 40, 2, p. 119-130.e9, 12 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article