Prof. Dr. Ingmar Glauche
© Ingmar Glauche
Group leader
NameMr Prof. Dr. rer. med. Ingmar Glauche
Deputy Institute Director
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Ingmar Glauche is deputy head of the Institute for Medical Informatics and Biometrics and leads the research group for Theoretical Stem Cell Biology. He is the coordinator of institute's teaching activities. Professor Dr. Glauche represents the Medical Faculty as an elected member of the extended senate of TU Dresden. Additionally, Professor Dr. Glauche serves as a voluntary conflict mediator at TU Dresden.
Prof. Dr. Glauche’s research focus covers the following areas:
Hematopoietic stem cell aging:
- Clonal competition and clonal dominance
- Age-related changes in the polarity of HSC divisions
Theoretical concepts of stem cell organization:
- Proliferation- and differentiation control of haematopoietic stem cells
- Clonal competition phenomena
- Cell fate regulation of mouse embryonic stem cells
Disease and treatment models:
- Chronic and acute myeloid leukaemia
- Conceptual understanding of inherited bone marrow failure syndromes
- Gene therapeutic approaches
Statistical analysis of dynamic processes and structures
- Image analysis and single cell tracking
- Analysis of cellular genealogies
Clonal tracking
- Genetic barcoding
- Analysis of multiple integrations
Publications
2011
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Cellular aging leads to functional heterogeneity of hematopoietic stem cells: a modeling perspective, Jun 2011, In: Aging cell. 10, 3, p. 457-465, 9 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Towards a quantitative understanding of stem cell-niche interaction: experiments, models, and technologies, 15 Apr 2011, In: Blood cells, molecules & diseases : BCMD. 46, 4, p. 308-17, 10 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Immunohistochemical and Flow Cytometric Analysis of Long-Term Label-Retaining Cells in the Adult Heart., Feb 2011, In: Stem Cells and Development. 20, 2, p. 211-222, 12 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
2010
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Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis, 21 Jun 2010, In: PLoS ONE. 5, 6, p. e11238Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Towards a Cellular Genealogy Ontology, 2010, 2nd Workshop of the GI-Fachgruppe "Ontologien in Biomedizin und Lebenswissenschaften (OBML)", 09-10. September 2010 in Mannheim. Universität LeipzigElectronic (full-text) versionResearch output: Contribution to book/conference proceedings/anthology/report > Chapter in book/Anthology/Report
2009
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Stem cell proliferation and quiescence--two sides of the same coin, Jul 2009, In: PLOS computational biology. 5, 7, e1000447Electronic (full-text) versionResearch output: Contribution to journal > Research article
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A novel view on stem cell development: Analysing the shape of cellular genealogies, Apr 2009, In: Cell Proliferation. 42, 2, p. 248-263, 16 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
2008
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Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia--insights from mathematical model analyses, Jan 2008, In: Journal of Molecular Medicine. 86, 1, p. 17-27, 11 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
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Correlation patterns of cellular genealogies, 2008, Fifth International Workshop on Computational Systems Biology (WCSB), June 11–13 2008. p. 161-164Research output: Contribution to book/conference proceedings/anthology/report > Conference contribution
2007
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Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications, Jul 2007, In: Stem cells (Dayton, Ohio). 25, 7, p. 1791-9, 9 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
This information is provided by the FIS.